952 Topical nicotinic receptor activation improves wound bacterial infection outcomes by suppressing TLR2-mediated inflammation in diabetic wounds
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چکیده
منابع مشابه
Topical nanoemulsion therapy reduces bacterial wound infection and inflammation after burn injury.
BACKGROUND Nanoemulsions are broadly antimicrobial oil-in-water emulsions containing nanometer-sized droplets stabilized with surfactants. We hypothesize that topical application of a nanoemulsion compound (NB-201) can attenuate burn wound infection. In addition to reducing infection, nanoemulsion therapy may modulate dermal inflammatory signaling and thereby lessen inflammation following therm...
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Macrophages are essential immune cells necessary for regulated inflammation during wound healing. Recent studies have identified that Notch plays a role in macrophage-mediated inflammation. Thus, we investigated the role of Notch signaling on wound macrophage phenotype and function during normal and diabetic wound healing. We found that Notch receptor and ligand expression are dynamic in wound ...
متن کاملTopical Hypericum perforatum Improves Tissue Regeneration in Full-Thickness Excisional Wounds in Diabetic Rat Model
Delayed wound healing process is one of the most important concerns in diabetes. Healing of wounds has four phases, namely, hemostasis, inflammation, proliferation, and remodeling. For a successful repair, all four factors must occur properly. Hence, we aimed to evaluate the healing effects of Hypericum perforatum (HP) on full-thickness diabetic skin wounds by using stereological methods. Forty...
متن کاملTopical Green Propolis Improves Corneal Wound Healing and Inflammation in Rats following Alkaline Burns
Background: The objective of this study was to investigate the effects of green propolis, a widely used folk medicine, in corneal wound healing and inflammation. Methods: Epithelial defects of 1mm in diameter were made in the right corneas of Wistar male adult rats by cauterization with silver nitrate sticks. Subsequently, they were divided in two groups (n=40 rats/group): group green propolis ...
متن کاملTopical Brazilian propolis improves corneal wound healing and inflammation in rats following alkali burns
BACKGROUND The objective of this study was to investigate the effects of the Brazilian Scaptotrigona sp propolis, a widely used folk medicine, in corneal wound healing and inflammation. METHODS Corneal epithelial defects of 1 mm in diameter were made in the right eyes of Wistar male adult rats by cauterization with silver nitrate sticks. Subsequently, they were divided in two groups (n = 40 r...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2019
ISSN: 0022-202X
DOI: 10.1016/j.jid.2019.03.1028